Interferon-Stimulated Genes
Gene co-expression module in Innate lymphoid cells
| Category | Inflammation |
|---|---|
| Genes | 26 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 2 of 26 genes have a known function matching the annotation |
Why this annotation
IFITM1 and IFITM3 are interferon-stimulated genes (ISGs) that restrict viral entry. ZYX (zyxin) is a focal adhesion/cytoskeletal protein. VCP is involved in protein quality control and ER-associated degradation. ALDOA is glycolytic. SYNGR2 and RAB11B are vesicle trafficking proteins. GNB2 is a G-protein beta subunit. The presence of IFITM1/3 as notable members alongside a mixed housekeeping background suggests a weak interferon-stimulated gene signature co-expressed with general ILC1 programs. The module is heterogeneous.
Genes
ALDOA, CRTAP, DAZAP2, DDX39B, EIF4B, GDI1, GNB2, GRINA, GSTM2, IFITM1, IFITM3, IGFBP4, KHDRBS1, MARCHF3, MTHFS, PCBP1, PTPRCAP, RAB11B, RELB, RPN1, SDF4, SYNGR2, TMEM179B, TTC7A, VCP, ZYX
Most correlated modules
- Cellular Metabolic Maintenance · correlation 0.85
- NK Activating Receptors · correlation 0.81
- Cell Cycle Regulation · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.