FLI1 — Fli-1 proto-oncogene, ETS transcription factor
FLI1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FLI1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | T cell Survival T cell maturation | ARFRP1, BCL2L1, C6orf47, CHD9, DAXX, DEF6, DENND2D, DHPS +26 more | |
| Innate lymphoid cells | Cell Cycle Regulation Cell cycle | CDKN1B, GLG1, KIF2A, RAD21, TAF15, TBRG1 | View in SCUBA |
| Macrophages | Myeloid Signaling Regulation Innate immunity | ADGRG6, AOAH, CCDC170, CD302, CMKLR1, CPED1, DIPK2A, FAM13A +38 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Epigenetic Regulation DNA/chromatin regulation | ACAP2, APBB1IP, ARHGAP25, ATM, CD247, CHD9, CLCN3, DDX17 +14 more | |
| Neutrophils | Granulopoiesis Program Developmental | ARHGAP24, ARID1B, B4GALT5, CSGALNACT1, IQGAP2, LYST, PDZD8, PHIP +5 more | |
| Pericytes | MHC-II Antigen Presentation Inflammatory | CD74, CIITA, CYYR1, HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQB1 +4 more | View in SCUBA |
About the gene
| Synonyms | EWSR2, FLI-1, SIC-1 |
|---|---|
| Chromosome | 11: 128686535-128813267 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'- C[CA]GGAAGT-3'.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.