RNA Processing
Gene co-expression module in Innate lymphoid cells
| Category | RNA processing & translation |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 12 genes have a known function matching the annotation |
Why this annotation
NOP53 (GLTSCR2) is involved in ribosome biogenesis and p53 stabilization. SRSF5 and HNRNPH2 are splicing factors (serine/arginine-rich and heterogeneous nuclear ribonucleoprotein families). RBM4 is an RNA-binding protein regulating alternative splicing. CNOT6L is a component of the CCR4-NOT deadenylase complex regulating mRNA stability and decay. MAPRE1 (EB1) tracks microtubule plus ends but also has roles in mRNA localization. The module is dominated by RNA processing and post-transcriptional regulation genes. CD53 and C1orf56 are outliers. Moderate coherence with mostly weak membership supports a loosely coordinated RNA processing program.
Genes
C1orf56, CD53, CNOT6L, EVI2A, HNRNPH2, HSD17B11, MAPRE1, METTL15, NOP53, PET100, RBM4, SRSF5
Most correlated modules
- Lymphocyte Apoptosis Regulation · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.