Lymphocyte Apoptosis Regulation
Gene co-expression module in Innate lymphoid cells
| Category | Immune regulation |
|---|---|
| Genes | 23 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes STK4 and STK17A are pro-apoptotic serine/threonine kinases (STK4/MST1 is a core Hippo/apoptosis kinase; STK17A/DRAK2 promotes lymphocyte apoptosis). ARMCX3 links to mitochondrial apoptosis regulation. ELF1 is a lymphocyte-expressed ETS transcription factor regulating survival. CHD2 is a chromatin remodeler involved in DNA damage response. WIPF1 connects actin dynamics to apoptotic signaling. The module is moderate coherence with mostly weak membership, suggesting a loosely coordinated lymphocyte survival/apoptosis regulatory program rather than a tight single pathway.
Genes
ANP32B, ARMCX3, CCDC69, CHD2, DHRS7, ELF1, FXYD5, GLIPR1, LEPROTL1, MBOAT7, PHF20, PPP1R2, PRKX, RBMS1, SACM1L, SARAF, STK17A, STK4, TNFSF11, TOMM20, UBXN1, VPS51, WIPF1
Most correlated modules
- IFN-driven ILC1 Activation · correlation 0.80
- NK Receptor Signaling · correlation 0.77
- NK/ILC1 Identity · correlation 0.75
- cAMP-Glucocorticoid Suppression · correlation 0.75
- RNA Processing · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.