SCUBA

SRSF5 — Serine and arginine rich splicing factor 5

SRSF5 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SRSF5's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsmRNA Splicing
RNA processing
AFF4, ARL6IP1, CALR, CCNL1, CLK1, DDX3X, DDX5, EIF4A2 +7 moreView in SCUBA
FibroblastsFibroblast Quiescence
Housekeeping
BTG1, EIF1, EIF4A2, FNIP1, ID2, KLF2, KLF4, RHOB +5 moreView in SCUBA
Gamma-delta T cellsER Proteotoxic Stress
Stress
ARL4A, BCAS2, CCDC59, CSRNP1, CYCS, EIF5, EXOSC6, FOSB +13 more
Glial cellsGlial Quiescence State
Development
AATK, CDKN1C, FADS3, PPP1R10, RGCC, RSRP1, SLC38A2, SOX2View in SCUBA
Goblet cellsmRNA Stability Control
RNA processing & translation
BTG1, DNAJB6, PNRC1, TENT5C, TSC22D1, TUBA1A, TXNIP, UBXN1 +5 moreView in SCUBA
Innate lymphoid cellsRNA Processing
RNA processing & translation
C1orf56, CD53, CNOT6L, EVI2A, HNRNPH2, HSD17B11, MAPRE1, METTL15 +3 moreView in SCUBA
MacrophagesPre-mRNA Splicing
Housekeeping
BCLAF1, CSNK1A1, DDX3X, DDX5, EWSR1, FUS, HNRNPH1, HNRNPH3 +11 moreView in SCUBA
Mucosal-associated invariant T cellIntegrated Stress Response
Stress
ATF4, EIF4A3, EIF5, FAM53C, IFRD1, MARCKSL1, MKNK2, ODC1 +7 more
Natural Killer cellsTGF-β Antagonism
Immune regulation
IFRD1, IRS2, MOB3A, RBM39, SBDS, SMAD7, STK17B, ZBTB1 +1 moreView in SCUBA

About the gene

SynonymsHRS, SFRS5, SRP40
Chromosome14: 69726900-69772005
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins
Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Function

Plays a role in constitutive splicing and can modulate the selection of alternative splice sites

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.