NOP53 — NOP53 ribosome biogenesis factor
NOP53 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NOP53's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Translation Elongation RNA processing & translation | CCNI, COMMD6, EEF1A1, EEF1B2, EEF2, EIF3F, EIF3L, EIF4B +7 more | View in SCUBA |
| Fibroblasts | Microfibril ECM Fibroblast ECM production | CD302, CD81, COX7C, CYBRD1, EPHX1, MFAP4, NFIX, NUCKS1 +2 more | View in SCUBA |
| Gamma-delta T cells | ATP Synthase Complex Mitochondrial & OxPhos | ATP5F1D, ATP5F1E, ATP5MC2, ATP5MC3, ATP5MF, ATP5MG, ATP5MK, ATP5PD +23 more | |
| Goblet cells | RNA Splicing RNA processing & translation | ARGLU1, C6orf62, EPHB3, FUS, HNRNPH1, HNRNPU, LUC7L3 | View in SCUBA |
| Innate lymphoid cells | RNA Processing RNA processing & translation | C1orf56, CD53, CNOT6L, EVI2A, HNRNPH2, HSD17B11, MAPRE1, METTL15 +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | TGF-beta Response Immune regulation | ABCA1, ARL4C, ARRDC2, CD48, DDX47, DNLZ, ERGIC1, FMNL1 +21 more | |
| Natural Killer cells | Translation Elongation RNA processing & translation | BTF3, COMMD6, EEF1A1, EEF1B2, EEF1D, EIF3E, NACA, PFDN5 +3 more | View in SCUBA |
About the gene
| Synonyms | GLTSCR2, PICT-1, PICT1 |
|---|---|
| Chromosome | 19: 47745546-47757058 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Host-virus interaction, Ribosome biogenesis |
Function
Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation. It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation. Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway. May also inhibit cell proliferation and increase apoptosis through its interaction with NF2. May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation. Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex. May also regulate cellular aerobic respiration. In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of RIGI.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.