snRNP Splicing Complex
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
Hub gene BANF1 (barrier-to-autointegration factor) is a nuclear envelope/chromatin organization protein. LSM2 (Sm-like protein 2) participates in pre-mRNA splicing and mRNA decay. SNRPD1, SNRPF, SNRPC, SNRPB are all core Sm proteins of the spliceosomal snRNP complex — four snRNP genes make this the dominant program. MRPL51, MRPL11, MRPL22, MRPL47 are mitoribosomal large subunit proteins (4 genes). NME1 (nucleoside diphosphate kinase), GTF3A (TFIIIA transcription factor), MAGOH (exon junction complex/splicing). The snRNP splicing program is the strongest signal by gene count and hub gene identity. Neighbor context: M74 also contains SNRPG/SNRPD3, confirming a shared snRNP splicing neighborhood. The mitoribosomal genes likely co-express due to shared transcriptional regulation of housekeeping programs.
Genes
Most correlated modules
- snRNP RNA Processing · correlation 0.98
- SUMOylation & Splicing · correlation 0.97
- ER Protein Processing · correlation 0.95
- Mitochondrial Complex I · correlation 0.94
- TRiC Chaperonin Complex · correlation 0.93
- ER Protein Folding · correlation 0.92
- ER Protein Trafficking · correlation 0.92
- Nuclear RNA Transport · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.