snRNP RNA Processing
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include SRP9 (signal recognition particle 9kDa subunit), SNRPG and SNRPD3 (core snRNP proteins involved in pre-mRNA splicing), and LSM3 (Sm-like protein in splicing/mRNA decay). Supporting members include MRPL13 (mitoribosomal), VDAC3 (mitochondrial outer membrane), GLRX5 (iron-sulfur cluster assembly), VPS29 (retromer complex), and RBX1 (SCF ubiquitin ligase). The top-ranked genes by PageRank are predominantly RNA processing factors (SRP, snRNPs), making RNA processing the dominant program. Uniform expression and CD-specific downregulation with treatment recovery are consistent with a constitutive housekeeping RNA processing module. Neighbor context: this module sits adjacent to M44 (snRNP-heavy) and M51 (protein processing), consistent with a housekeeping RNA/protein biogenesis neighborhood.
Genes
Most correlated modules
- snRNP Splicing Complex · correlation 0.98
- SUMOylation & Splicing · correlation 0.96
- ER Protein Processing · correlation 0.95
- ER Protein Trafficking · correlation 0.94
- Mitochondrial Complex I · correlation 0.94
- Metabolic Housekeeping · correlation 0.94
- Mitochondrial Metabolism · correlation 0.94
- TRiC Chaperonin Complex · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.