TRiC Chaperonin Complex
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
Hub gene XRCC5 (Ku80) is a key DNA double-strand break repair protein (NHEJ). KHDRBS1 (Sam68) is an RNA-binding protein involved in splicing and signal transduction. PA2G4 (ErbB3-binding protein/Ebp1) is involved in ribosome biogenesis and proliferation. ACTL6A is a subunit of the BAF chromatin remodeling complex. CCT2, CCT6A, CCT8 are three subunits of the TRiC/CCT chaperonin complex (protein folding). GLO1 (glyoxalase I, detoxification), LDHB (lactate dehydrogenase B, glycolysis), PPM1G (protein phosphatase), MESD (WNT co-receptor chaperone), MORF4L1 (NuA4 histone acetyltransferase complex), IMPDH2 (IMP dehydrogenase, purine biosynthesis), SNRNP40 (splicing). This is a mixed module combining chaperonin folding, DNA repair, and chromatin regulation. The TRiC chaperonin subunits (3 genes) and XRCC5 are the strongest anchors. Given the mixed nature, the chaperonin/protein folding program is most represented. Neighbor context: adjacent to M45 (also contains CCT5), suggesting a shared chaperonin co-expression program across modules.
Genes
Most correlated modules
- Housekeeping Transcription · correlation 0.94
- Chromatin RNA Processing · correlation 0.94
- snRNP RNA Processing · correlation 0.94
- snRNP Splicing Complex · correlation 0.93
- SUMOylation & Splicing · correlation 0.93
- ER Protein Folding · correlation 0.92
- ER Targeting & Trafficking · correlation 0.92
- RNA Processing Translation · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.