Mitochondrial Sulfur Detox
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 10 genes have a known function matching the annotation |
Why this annotation
Top hub ETHE1 is a mitochondrial sulfur dioxygenase involved in hydrogen sulfide catabolism; TST (thiosulfate sulfurtransferase/rhodanese) converts thiosulfate to thiocyanate, also part of H2S detoxification; MGST3 is a mitochondrial glutathione S-transferase. FAM162A is a hypoxia-inducible mitochondrial protein. Together ETHE1, TST, MGST3, and AKR7A3 (aldo-keto reductase, detoxification) define a mitochondrial sulfur/reactive species detoxification program. LGALS3 (galectin-3, inflammation/apoptosis), SRI (sorcin), RABAC1, S100A10, CHMP2A are peripheral. Strongly downregulated in both UC and CD inflammation, restored by CD treatment. The mitochondrial sulfur detox program is consistent with colonocyte-specific H2S metabolism.
Genes
Most correlated modules
- Mitochondrial Membrane · correlation 0.95
- Oxidative Phosphorylation · correlation 0.94
- Oxidative Phosphorylation · correlation 0.93
- TCA Cycle OxPhos · correlation 0.92
- Epithelial Lipid Homeostasis · correlation 0.91
- Mitochondrial Complex I · correlation 0.90
- Oxidative Phosphorylation · correlation 0.90
- Metabolic Housekeeping · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.