ER Protein Translocation
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes SSR1 (signal sequence receptor alpha), RPN2 (dolichyl-diphosphooligosaccharide-protein glycosyltransferase), PDIA3 (protein disulfide isomerase), DNAJC3 (ER-resident DnaJ co-chaperone), TRAM1 (translocon-associated membrane protein), LMAN2 (ER-Golgi lectin), TMED10 (p24 family COPI vesicle cargo receptor), and COPB2 (COPI coat beta subunit) collectively define the ER protein translocation, N-glycosylation, and ER-to-Golgi vesicular transport machinery. All genes are uniformly expressed and show strong module membership. Upregulation in UC inflammation is consistent with increased secretory/ER load. Neighbor M24 and M42 also involve ER/trafficking genes, reinforcing this ER-centric neighborhood.
Genes
Most correlated modules
- Epithelial Cell Adhesion · correlation 0.94
- ER Protein Trafficking · correlation 0.93
- ER Membrane Organization · correlation 0.92
- ER Protein Folding · correlation 0.92
- Metabolic Housekeeping · correlation 0.91
- ER Targeting & Trafficking · correlation 0.90
- Mitochondrial Cristae Organization · correlation 0.88
- RNA Processing Translation · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.