Polycomb Repression
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 24 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes CBX4 (PRC1 component) and CTBP1 (transcriptional co-repressor linked to Polycomb) anchor a chromatin/epigenetic repression program. UBE2M (neddylation E2) and BTBD6 (Cullin3 adaptor) indicate active ubiquitin/neddylation-mediated protein regulation, often tied to chromatin modifier turnover. YTHDF1 (m6A reader) and DUS1L (tRNA modification) extend the program to RNA-level regulation. LFNG (Notch pathway glycosylation), CSNK1G2 (Wnt-associated kinase), and GNB1 (G-protein signaling) add regulatory signaling context. Uniform expression across subsets and strong coherence suggest a constitutive, cell-intrinsic regulatory program rather than an activation state. The dominant theme is Polycomb/ubiquitin-mediated chromatin and transcriptional repression.
Genes
BTBD6, CBX4, CD81, CSNK1G2, CTBP1, DUS1L, GNB1, GRK6, H2AC17, LFNG, METRN, NCK2, PGAP6, PPP1R14B, RNPEPL1, SH3GLB2, SLC2A4RG, SRM, SSBP3, TESK1, TMEM238, UBE2M, VEGFB, YTHDF1
Most correlated modules
- PI3K MAPK Signaling · correlation 0.64
- AP-1 Immediate Early · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.