AP-1 Immediate Early
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Stress |
|---|---|
| Genes | 26 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 26 genes have a known function matching the annotation |
Why this annotation
JUNB and JUN are canonical AP-1 immediate early response transcription factors. IER2 and IER5L are immediate early response genes induced by mitogenic and stress stimuli. GADD45B is a stress and DNA damage response gene. H2AX (γH2AX marks DNA double-strand breaks) indicates DNA damage. CITED2 is a hypoxia/stress-responsive CBP coactivator. HEXIM1 inhibits P-TEFb and controls transcriptional elongation during stress. SNAI1 is an AP-1-regulated transcriptional repressor. ID2 is regulated by AP-1 and involved in T cell differentiation. SLC38A2 is an amino acid transporter upregulated in stress (integrated stress response). AMD1 is involved in polyamine synthesis. This module strongly resembles an immediate early/AP-1 stress response program.
Genes
AMD1, BRD2, CITED2, CSKMT, FUS, GADD45B, GADD45G, H2AX, HEXIM1, HSPA2, ID2, IER2, IER5L, ING1, INTS6, JUN, JUNB, MYLIP, NUFIP2, PTCH2, SLC38A2, SNAI1, TMEM107, TUBA1B, WDR74, WSB1
Most correlated modules
- Dissociation Stress Response · correlation 0.81
- Integrated Stress Response · correlation 0.74
- PI3K MAPK Signaling · correlation 0.71
- Mitochondrial Quality Control · correlation 0.67
- Heat Shock Response · correlation 0.66
- RNA Splicing m6A · correlation 0.66
- Polycomb Repression · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.