NCK2 — NCK adaptor protein 2
NCK2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NCK2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Naive B cell B cell maturation | ABCB1, ABCB4, BTLA, C1orf162, CD200, COL19A1, DSP, FCER2 +15 more | View in SCUBA |
| Gamma-delta T cells | GPCR-AKT-MAPK Signaling TCR Signaling | ADNP, AKT1, ALYREF, B3GALT6, BRD4, BRI3, BTBD6, CENPB +29 more | |
| Innate lymphoid cells | ILC3 identity Differentiation | BHLHE40, BRD4, CASK, CITED2, GLUL, GNAS, HECA, IGFBP7 +19 more | View in SCUBA |
| Mucosal-associated invariant T cell | Polycomb Repression DNA/chromatin regulation | BTBD6, CBX4, CD81, CSNK1G2, CTBP1, DUS1L, GNB1, GRK6 +15 more | |
| Pericytes | Pericyte Identity Cytoskeletal | ABCC9, ARHGAP42, ARHGEF17, ECM2, EDNRA, EGFLAM, GJC1, LHFPL6 +2 more | View in SCUBA |
About the gene
| Synonyms | NCKbeta |
|---|---|
| Chromosome | 2: 105744912-105894274 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | Translation regulation |
Function
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.