PI3K MAPK Signaling
Gene co-expression module in Mucosal-associated invariant T cell
| Category | TCR Signaling |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
AKT1 (PI3K/Akt), GRK2 (GPCR kinase that interacts with AKT), MAP2K2 (MEK2/MAPK cascade), PKN1 (PKC-related kinase), GNAS (Gαs, GPCR signaling), CALM2 (calmodulin, calcium signaling) constitute a PI3K/MAPK/GPCR signaling hub. YBX1 and PCBP1/PCBP2 are stress-responsive RNA-binding proteins also regulated by Akt. TRIM28 and BRD4 link to chromatin-level transcriptional control downstream of kinase signaling. This module reflects integrated PI3K-MAPK kinase signaling in MAIT cells.
Genes
AKT1, APH1A, BRD4, CALM2, CMTM3, DAZAP1, GNAS, GRK2, MAP2K2, MAZ, MBD2, P4HB, PCBP1, PCBP2, PKN1, STK24, TMEM259, TRIM28, UBALD2, YBX1
Most correlated modules
- RNA Splicing m6A · correlation 0.85
- NF-κB Activation · correlation 0.75
- AP-1 Immediate Early · correlation 0.71
- Polycomb Repression · correlation 0.64
- NF-κB Survival Signaling · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.