SCUBA

GNB1 — G protein subunit beta 1

GNB1 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

GNB1's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsIntegrin Adhesion Migration
migration & adhesion
ARAP2, ATF7IP, C4orf3, CLEC2B, COTL1, CTSH, DEK, DIAPH1 +11 moreView in SCUBA
CD8⁺ T cellsChromatin RNA Processing
RNA processing & translation
CHD4, EIF4G2, FLNA, MTDH, SFPQ, SRSF11, UBXN4, ZNF207View in SCUBA
EndothelialWAVE Complex Cytoskeleton
Cytoskeletal
ATP2B4, C6orf89, CD46, CYFIP1, DYNC1LI2, GIT1, IQGAP1, MAP7D1 +3 moreView in SCUBA
FibroblastsActin-Integrin Adhesion
Migration & adhesion
ACTR2, ACTR3, C5orf24, CAP1, CD151, DEGS1, FERMT2, ITGB1 +5 moreView in SCUBA
Gamma-delta T cellsGPCR-AKT-MAPK Signaling
TCR Signaling
ADNP, AKT1, ALYREF, B3GALT6, BRD4, BRI3, BTBD6, CENPB +29 more
Lymphatic endothelialActomyosin Contractility
Cytoskeletal
AFAP1L1, C1orf21, COBLL1, EEA1, MAP4, OSBPL8, PPP1R12A, ROCK1 +6 moreView in SCUBA
MacrophagesRAB-mediated Trafficking
Vesicular traficking
ABI1, ACSL3, ARMC8, CACUL1, CD86, CHST15, CRTC3, CTNNA1 +27 moreView in SCUBA
Mucosal-associated invariant T cellPolycomb Repression
DNA/chromatin regulation
BTBD6, CBX4, CD81, CSNK1G2, CTBP1, DUS1L, GRK6, H2AC17 +15 more
PericytesG-protein Signaling Scaffold
Housekeeping
BCAP29, FDPS, GNB2, PPIA, RAC1, RAP1A, TRIR, YWHAB +1 moreView in SCUBA

About the gene

Chromosome1: 1785285-1892292
Predicted locationIntracellular
Essential geneNo
Protein classCancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins, Transporters
Molecular functionTransducer
Biological processHost-virus interaction

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.