Lipid Mediator Signaling
Gene co-expression module in Microfold-like cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
PTAFR (platelet-activating factor receptor) mediates inflammatory lipid signaling; AKR1C2 is an aldo-keto reductase involved in steroid/lipid metabolism; SLC27A3 is a fatty acid transporter; TNFRSF11B (osteoprotegerin) is a decoy TNFR with anti-apoptotic and immunomodulatory roles; SERPINE2 (protease nexin-1) inhibits serine proteases. The module centers on lipid mediator signaling (PAF receptor) and fatty acid metabolism, consistent with a lipid-handling macrophage state. Neighbors M99 and M70 also involve lipid catabolism, reinforcing this theme.
Genes
Most correlated modules
- Interferon Chemokine Response · correlation 0.99
- IL1B Inflammatory Macrophage · correlation 0.99
- Phagocytic Lipid Catabolism · correlation 0.99
- Vesicle Membrane Trafficking · correlation 0.97
- Tissue-protective Macrophage · correlation 0.97
- Non-canonical NF-κB · correlation 0.96
- Signaling Suppression · correlation 0.95
- Sphingolipid Membrane Organization · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.