Interferon Chemokine Response
Gene co-expression module in Microfold-like cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
IFI6 is a canonical interferon-stimulated gene (ISG). CX3CL1 (fractalkine) is an inflammatory chemokine produced by macrophages to recruit NK cells and T cells. PLAU (urokinase-type plasminogen activator) is upregulated in inflammatory macrophages and drives ECM remodeling. GSN (gelsolin) participates in actin remodeling during inflammatory activation. MYOF (myoferlin) is involved in membrane repair and vesicle fusion. The combination of an ISG, an inflammatory chemokine, and a plasminogen activator points to an interferon-driven inflammatory macrophage program with chemokine secretion.
Genes
Most correlated modules
- Lipid Mediator Signaling · correlation 0.99
- Vesicle Membrane Trafficking · correlation 0.99
- Signaling Suppression · correlation 0.98
- Phagocytic Lipid Catabolism · correlation 0.97
- IL1B Inflammatory Macrophage · correlation 0.97
- Non-canonical NF-κB · correlation 0.97
- Tissue-protective Macrophage · correlation 0.96
- Complement Macrophage Activation · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.