Signaling Suppression
Gene co-expression module in Microfold-like cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include multiple negative regulators of intracellular signaling: TNFAIP3 (A20, NF-κB suppressor), PTPN12 (tyrosine phosphatase), RASA1 (Ras GAP), SRGAP1 (Rho GAP), alongside vesicle/cytoskeletal genes KIF13B, DMXL1, AGAP1, SHTN1. The module reflects a macrophage homeostatic program dampening inflammatory signaling cascades. SMARCA2 adds chromatin-level regulation. Uniform expression across subsets and mild UC inflammation association support a baseline regulatory macrophage state rather than a specific activation program.
Genes
Most correlated modules
- Vesicle Membrane Trafficking · correlation 0.98
- Interferon Chemokine Response · correlation 0.98
- Stress Survival Response · correlation 0.98
- Non-canonical NF-κB · correlation 0.97
- Lipid Mediator Signaling · correlation 0.95
- Complement Macrophage Activation · correlation 0.95
- Oxidative Stress ROS · correlation 0.94
- Phagocytic Lipid Catabolism · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.