IL1B Inflammatory Macrophage
Gene co-expression module in Microfold-like cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
IL1B (canonical pro-inflammatory cytokine) and PTGS1 (COX-1, prostaglandin synthesis) anchor this as an inflammatory macrophage module. ENPP2 (autotaxin, produces lysophosphatidic acid - a lipid mediator of inflammation), SCARA5 (scavenger receptor), RASSF2 (pro-apoptotic Ras effector), PON3 (antioxidant lipid metabolism), and CAV2 (caveolin-2, lipid raft signaling) support a lipid-mediator-driven inflammatory program. The strong treatment-negative delta and UC inflammation association confirm active inflammatory signaling. PROX1 and NFASC are less typical but may reflect macrophage plasticity in the colon microenvironment.
Genes
Most correlated modules
- Lipid Mediator Signaling · correlation 0.99
- Phagocytic Lipid Catabolism · correlation 0.98
- Interferon Chemokine Response · correlation 0.97
- Tissue-protective Macrophage · correlation 0.95
- Vesicle Membrane Trafficking · correlation 0.95
- Sphingolipid Membrane Organization · correlation 0.95
- Complement Macrophage Activation · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.