Contractile Tone Regulation
Gene co-expression module in Smooth muscle cells
| Category | Contractility |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
SPEG (striated/smooth muscle-enriched protein kinase, essential for SMC differentiation), HSPB6 (HSP20, cAMP/PKA-dependent relaxation), PDE5A (cGMP phosphodiesterase controlling NO-mediated relaxation), RGS3 (GPCR contractile signaling termination) and RNF150/FAM13C (RhoGAP-family, SMC-enriched) define a mature contractile/relaxation-tone program, accompanied by small leucine-rich proteoglycans of the muscle-adjacent matrix (PRELP, ASPN, SBSPON) that are typical of differentiated SMC niches. This is the differentiated counterpart to the neighboring synthetic/ECM module M61, and their co-occurrence in the same neighborhood reflects the contractile-vs-synthetic phenotypic axis of colonic smooth muscle.
Genes
ASPN, FAM13C, HAGH, HSPB6, PDE5A, PJA2, PRELP, RGS3, RNF150, SBSPON, SPEG
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.