PDE5A — Phosphodiesterase 5A
PDE5A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDE5A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Homeostatic Stromal Identity ECM production | ADAMTSL1, ADAMTSL3, EPB41L2, KAZALD1, LRIG1, NFIB, NUPR1, PLXDC1 +4 more | View in SCUBA |
| Smooth muscle cells | Contractile Tone Regulation Contractility | ASPN, FAM13C, HAGH, HSPB6, PJA2, PRELP, RGS3, RNF150 +2 more | View in SCUBA |
About the gene
| Chromosome | 4: 119494397-119628804 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Allosteric enzyme, Hydrolase |
Function
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide- generated cGMP.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.