RGS3 — Regulator of G protein signaling 3
RGS3 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RGS3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Tone Regulation Endothelial cell development | ADAMTS6, ATP1A1, ATP1B3, ATP5PF, CALD1, CAVIN3, CCDC3, CD81 +13 more | View in SCUBA |
| Fibroblasts | Activated Myofibroblast State Wound healing | BGN, BMP1, CPXM1, CTHRC1, EGFL6, FAP, KIAA0930, MASP1 +7 more | View in SCUBA |
| Gamma-delta T cells | Antiviral ISG Response Inflammation | ACTR1A, ATRX, CD164, CYTH4, FGD3, GIT2, LASP1, PARP10 +6 more | |
| Mucosal-associated invariant T cell | ER Stress Response Protein processing & ER | ACADVL, APOL3, GYG1, HLA-F, HSP90B1, LENG8, MAP4K1, PIM1 +4 more | |
| Pericytes | TGF-beta Negative Feedback Inflammatory | CTNND1, DAZAP2, EMP1, KAT6A, KBTBD2, KLF7, MLKL, RCAN1 +6 more | View in SCUBA |
| Smooth muscle cells | Contractile Tone Regulation Contractility | ASPN, FAM13C, HAGH, HSPB6, PDE5A, PJA2, PRELP, RNF150 +2 more | View in SCUBA |
About the gene
| Synonyms | C2PA, FLJ20370, PDZ-RGS3 |
|---|---|
| Chromosome | 9: 113444731-113597743 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Signal transduction inhibitor |
Function
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein- mediated release of inositol phosphates and activation of MAP kinases.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.