PJA2 — Praja ring finger ubiquitin ligase 2
PJA2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PJA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T-cell costimulation TCR/AP1/NFKb pathway | ASH1L, BOD1L1, CCM2, CCR4, CD28, CREBRF, DDX27, ERBIN +10 more | View in SCUBA |
| Gamma-delta T cells | T Cell Identity Program T cell maturation | ADA2, ADAM10, ARHGAP12, ATM, LPP, NLRC5, PIKFYVE, PRKCQ +5 more | |
| Macrophages | Ubiquitin-ERAD Proteostasis Housekeeping | GSPT1, HSPA9, ITCH, MAPK1IP1L, PANK3, SEL1L, TOR1AIP2, USP39 +1 more | View in SCUBA |
| Smooth muscle cells | Contractile Tone Regulation Contractility | ASPN, FAM13C, HAGH, HSPB6, PDE5A, PRELP, RGS3, RNF150 +2 more | View in SCUBA |
About the gene
| Synonyms | KIAA0438, Neurodap1, PRAJA2, RNF131 |
|---|---|
| Chromosome | 5: 109334713-109409974 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro- inflammatory M1 phenotype. Plays a role in ciliogenesis by ubiquitinating OFD1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.