IL1R2 — Interleukin 1 receptor type 2
IL1R2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL1R2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Regulatory T cell Immune regulation | ATP1B1, EBI3, FOXP3, GADD45A, GCNT1, GTF2H5, IL1R1, IPCEF1 +6 more | View in SCUBA |
| Goblet cells | Goblet Cell Identity Mucus production & secretion | AGR3, CA12, CD9, FAM162A, LGALS4, NDUFA1, SCP2, TMEM141 +1 more | View in SCUBA |
About the gene
| Synonyms | CD121b, IL1RB |
|---|---|
| Chromosome | 2: 101991960-102028544 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Receptor |
Function
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.