SPON1 — Spondin 1
SPON1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPON1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytokine signaling Immune regulation | ABCB1, ARHGEF40, AUTS2, COLQ, DSE, ERN1, GPR65, IFI44 +12 more | View in SCUBA |
| Enterocytes | Long-gene nuclear transcripts Technical artifact | ACSS2, CACNA1D, FREM1, GGT6, NAALADL2, PHYHIPL, PSD3, SUCLG2 +3 more | View in SCUBA |
| Hematopoietic progenitor cells | Lymphoid Progenitor Commitment Lymphcyte development | BASP1, CCR9, LRRC38, LSAMP, LZTFL1, MME, OSBPL3, SCN3A +3 more | |
| Smooth muscle cells | Microfibril ECM Assembly ECM remodeling | ADAM28, FBN2, ITGA9, NEO1, NID1, PROM1, PSD3, SERPINE2 +2 more | View in SCUBA |
About the gene
| Synonyms | f-spondin, KIAA0762 |
|---|---|
| Chromosome | 11: 13962723-14268133 |
| Predicted location | Secreted |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted secreted proteins |
| Biological process | Cell adhesion |
Function
Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.