Basement Membrane Remodeling
Gene co-expression module in Colonocytes
| Category | migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include LAMA3, LAMB3, LAMC2 (laminin-332 subunits, key basement membrane components for epithelial attachment and wound healing), BACH1 (transcription factor regulating oxidative stress and heme metabolism), FNDC3B (fibronectin domain), SESTD1 (SEC14 and spectrin domain), CTSB (cathepsin B, lysosomal protease involved in ECM remodeling), and RAPH1 (lamellipodin, cell migration). The laminin-332 trimer (α3β3γ2) is specifically upregulated during epithelial wound healing and in invasive/remodeling contexts. Mild inf_colono enrichment with inflammation upregulation suggests epithelial basement membrane remodeling during mucosal injury.
Genes
Most correlated modules
- IFN-γ Metabolic Reprogramming · correlation 0.95
- IFN-γ Antiviral Response · correlation 0.89
- TGF-β Chromatin Regulation · correlation 0.89
- Inflamed Barrier Remodeling · correlation 0.89
- TNF Apoptosis Resistance · correlation 0.88
- Oxidative Inflammatory Remodeling · correlation 0.87
- Inflammasome Pyroptosis · correlation 0.85
- Hypoxia-Inflammatory Reprogramming · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.