KLF Differentiation Response
Gene co-expression module in Colonocytes
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
KLF4 and KLF2 are Krüppel-like transcription factors critical for colonocyte differentiation and barrier integrity. TSC22D1 is a stress/glucocorticoid-responsive transcription factor. PDK4 encodes pyruvate dehydrogenase kinase 4, a metabolic switch gene induced during fasting/stress. TMPRSS4 is a serine protease associated with epithelial remodeling. ARL4A (top hub) is an ARF-like GTPase involved in cytoskeletal/membrane dynamics. STK39 is a stress-activated kinase. The module is significantly upregulated in UC inflammation (delta_inflammation=0.174 sig., delta_inflammation_UC=0.258 sig.), consistent with a stress-responsive colonocyte differentiation program. The KLF4/KLF2 axis and TSC22D1 point to transcriptional regulation of colonocyte identity under inflammatory stress.
Genes
Most correlated modules
- PPARG Lipid Metabolism · correlation 0.88
- EGFR Wound Response · correlation 0.78
- Cholesterol Biosynthesis · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.