PPARG Lipid Metabolism
Gene co-expression module in Colonocytes
| Category | Nutrient metabolism |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
PPARG is the top hub gene and master regulator of lipid metabolism and colonocyte differentiation. ABHD5 (CGI-58) activates adipose triglyceride lipase and is a direct PPARG target involved in lipid droplet metabolism. GCLM encodes the regulatory subunit of glutamate-cysteine ligase (rate-limiting for glutathione synthesis), and SOD1 is a key antioxidant enzyme — both are induced under oxidative stress and are PPARG-responsive. SH3BP1 (Rho GAP) and FAM107B are also present. Moderate coherence with some inf_colono enrichment for AXDND1/SOD1/GCLM suggests partial overlap with inflammatory oxidative stress. The module primarily represents PPARG-driven lipid handling with an oxidative stress component.
Genes
Most correlated modules
- KLF Differentiation Response · correlation 0.88
- Colonocyte Detoxification · correlation 0.88
- Ubiquitin Signaling Response · correlation 0.80
- Mitochondrial OxPhos · correlation 0.78
- Lipid Xenobiotic Metabolism · correlation 0.74
- Nuclear Receptor Signaling · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.