TSC22D1 — TSC22 domain family member 1
TSC22D1 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TSC22D1's module in each cell type
About the gene
| Synonyms | MGC17597, TGFB1I4, TSC22 |
|---|---|
| Chromosome | 13: 44432143-44577147 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional repressor. Acts on the C- type natriuretic peptide (CNP) promoter. Acts to promote CASP3-mediated apoptosis. Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1. Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4. Promotes TGF-beta- induced transcription of COL1A2; via its interaction with TFE3 at E- boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade. May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. Positively regulates cell death in response to TGFB3 during mammary gland involution
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.