Cholesterol Biosynthesis
Gene co-expression module in Colonocytes
| Category | Nutrient metabolism |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 15 genes have a known function matching the annotation |
Why this annotation
Nearly all hub genes are canonical cholesterol/sterol biosynthesis pathway components: HMGCR (rate-limiting HMG-CoA reductase), HMGCS1 (HMG-CoA synthase), FDFT1 (squalene synthase), FDPS (farnesyl diphosphate synthase), IDI1 (isopentenyl diphosphate isomerase), MSMO1 (methylsterol monooxygenase), SC5D (sterol C5-desaturase), NSDHL (sterol dehydrogenase), INSIG1 (SREBP pathway regulator), SREBF2 (SREBP2 transcription factor master regulator of cholesterol synthesis). This is a textbook mevalonate/cholesterol biosynthesis module. No significant inflammation response, suggesting constitutive colonocyte cholesterol homeostasis.
Genes
Most correlated modules
- Glycosylation & Membrane · correlation 0.86
- Ubiquitin Signaling Response · correlation 0.78
- Mitochondrial OxPhos · correlation 0.74
- KLF Differentiation Response · correlation 0.70
- Fatty Acid Oxidation · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.