KLF2 — KLF transcription factor 2

KLF2 belongs to a gene co-expression module in 16 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

KLF2's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	AP-1 Immediate Early BCR/AP1/NFKb pathway	BTG2, CD69, CD83, DUSP1, EIF1, FOS, FOSB, JUN +7 more	View in SCUBA
CD4⁺ T cells	Naive T quiescence T cell development	CCR7, CD55, CRIP2, CSGALNACT1, ITGA6, KLF3, NOSIP, RASA3 +6 more	View in SCUBA
CD8⁺ T cells	Naive/Central Memory T cell maturation	AIF1, ATM, CCR7, FCMR, FOXP1, KLF3, LDLRAP1, LEF1 +7 more	View in SCUBA
Endothelial	Shear Stress Response Stress	DNAJB1, DUSP1, EGR1, FOS, FOSB, HES1, HSP90AA1, HSPA1A +11 more	View in SCUBA
Fibroblasts	Fibroblast Quiescence Housekeeping	BTG1, EIF1, EIF4A2, FNIP1, ID2, KLF4, RHOB, SRSF5 +5 more	View in SCUBA
Gamma-delta T cells	Naive T cell quiescence T cell maturation	ADAP1, ARL4C, BCL9L, BMAL1, CALM1, CAMK1D, CD44, CD5 +10 more
Goblet cells	Hypoxia Metabolic Stress Stress	ADGRE5, ANKRD37, ARL4A, FBXO32, IRS2, LRRFIP1, SKIL, TENT5A	View in SCUBA
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, EZR, FOS +26 more	View in SCUBA
Lymphatic endothelial	AP-1 Immediate Early Inflammation	DUSP1, EGR1, FOS, FOSB, HES1, HSPA8, IER2, JUN +7 more	View in SCUBA
Macrophages	Anti-inflammatory Response Inflammatory	AMPD2, ARRDC2, BHLHE40, CBX4, CDKN1B, CEBPD, CITED2, DENND3 +31 more	View in SCUBA
Monocytes	ER Stress Response Stress	CDKN1B, CFAP20, DDIT3, GIMAP5, HSPA5, KLF4, ODC1, RHOB +2 more	View in SCUBA
Mucosal-associated invariant T cell	Vesicular Trafficking Housekeeping	ATP5PO, ATP6V1G1, CALM1, EEF1G, GET4, MED10, MZT2B, PSMD7 +5 more
Natural Killer cells	Mature NK Identity Cytotoxicity	GMFG, IFITM2, KLRD1, KLRF1, LYST, SAMD3, TSPO, XBP1	View in SCUBA
Neutrophils	KLF2 Survival Response Stress	BEST1, FOSB, IDS, JMJD1C, KLF6, MYADM, RASSF5, YPEL5 +1 more
Pericytes	Vascular Quiescence Developmental	HBEGF, ID2, KLF4, MIDN, MYLIP, PLK2, RHOB, SAT1 +1 more	View in SCUBA
Smooth muscle cells	Immediate Early Response Stress	ATF3, BTG1, BTG2, CDKN1A, EGR1, FOS, GADD45B, HES1 +7 more	View in SCUBA

About the gene

Synonyms	LKLF
Chromosome	19: 16324826-16328685
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Function

Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.