PDK4 — Pyruvate dehydrogenase kinase 4
PDK4 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDK4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | CYGB+ Quiescent Fibroblast Housekeeping | CCND1, CYGB, FARP1, FGFR4, FXYD5, NCAM1, NEGR1, NOVA1 +5 more | View in SCUBA |
| Goblet cells | BMP Signaling Response Epithelial development | CAMK2N1, CCND2, EIF4A2, GSTA1, GSTA4, ID2, ID3, ZBTB10 | View in SCUBA |
| Lymphatic endothelial | Heat Shock Response Stress | BAG3, DNAJB1, DNAJB4, HSP90AA1, HSPA1A, HSPA1B, HSPA6, HSPB1 +3 more | View in SCUBA |
| Macrophages | Myeloid Signaling Regulation Innate immunity | ADGRG6, AOAH, CCDC170, CD302, CMKLR1, CPED1, DIPK2A, FAM13A +38 more | View in SCUBA |
| Monocytes | Efferocytosis Tissue Macrophage Lysosomal & pahgocytosis | ADORA3, AKR1B1, CPM, FCHO2, GPR34, MERTK, SLC1A3, STARD13 | View in SCUBA |
About the gene
| Chromosome | 7: 95583499-95596516 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase |
Function
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.