Inflamed Barrier Remodeling
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 15 of 26 genes have a known function matching the annotation |
Why this annotation
This module is the most strongly inflammation-enriched in the batch (delta_inflammation=1.045, sig.; delta_UC=1.154, sig.) and significantly reverses with UC remission (delta_remission_UC=-0.816, sig.). Nearly all genes are enriched 2-6x in inf_colono. Hub genes: TPK1 (thiamine metabolism, metabolic stress), RHOD (Rho GTPase, vesicle motility), EPB41L2 (band 4.1L2, cytoskeletal-membrane scaffold), SDCBP (syntenin, syndecan signaling), CLDN12 (claudin-12, tight junction), SERPINB6/SERPINB8 (serine protease inhibitors, epithelial barrier defense), ITGA6 (integrin α6, basement membrane adhesion), NAMPT (NAD+ biosynthesis, metabolic stress sensor), ME1 (malic enzyme, NADPH production), CAPN8 (calpain-8, gastric/intestinal protease), MFSD2A (lipid transporter), AKIRIN2 (NF-κB nuclear import). The convergence of barrier proteins (claudins, integrins, serpins), metabolic reprogramming (NAMPT, ME1, TPK1), and NF-κB activation (AKIRIN2) defines a specific inflamed colonocyte barrier-stress program.
Genes
Most correlated modules
- IFN-γ Metabolic Reprogramming · correlation 0.90
- Epithelial Innate Immunity · correlation 0.90
- Basement Membrane Remodeling · correlation 0.89
- Inflammasome Activation · correlation 0.89
- Inflammasome Pyroptosis · correlation 0.88
- Membrane Repair Response · correlation 0.86
- IFN-γ Antiviral Response · correlation 0.85
- Integrin Adhesion Signaling · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.