TGF-β Chromatin Regulation
Gene co-expression module in Colonocytes
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes include TRIM56 (E3 ubiquitin ligase with innate immune/antiviral roles), ETV6 (ETS transcription factor), ZMYND8 (chromatin reader, transcriptional repressor), SMAD3 (TGF-β canonical effector), PKN2 (protein kinase N2, Rho effector), DOCK5 (Rho GEF), MACF1 (cytoskeletal crosslinker), SP140L (nuclear body, innate immunity), LYST (lysosomal trafficking regulator), and ARHGAP26 (Rho GAP). The module shows mostly uniform expression with mild inflammation upregulation. SMAD3 + ZMYND8 + ETV6 suggest a chromatin/transcriptional regulatory program. TRIM56 and SP140L add innate immune transcriptional context. This appears to be a broad transcriptional/chromatin regulatory module active in inflamed colonocytes, potentially downstream of TGF-β/SMAD3.
Genes
Most correlated modules
- Basement Membrane Remodeling · correlation 0.89
- IFN-γ Metabolic Reprogramming · correlation 0.89
- Epithelial Junction Integrity · correlation 0.88
- TNF Apoptosis Resistance · correlation 0.88
- Type I Interferon Response · correlation 0.88
- Inflammasome Pyroptosis · correlation 0.88
- IFN-γ Antiviral Response · correlation 0.87
- Senescent Cell Death · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.