IFN-γ MHC-II Response
Gene co-expression module in Fibroblasts
| Category | Inflammatory |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
The module is dominated by MHC class II genes (HLA-DQA1, HLA-DRB5, HLA-DRA, HLA-DRB1, HLA-DPA1, HLA-DPB1, CD74/invariant chain) alongside IFN-γ-induced chemokines CXCL9 and CXCL11, IDO1 (IFN-γ-induced immunosuppressive enzyme), GBP4 (guanylate-binding protein, IFN-γ target), and CALHM6. This is a canonical IFN-γ response program driving MHC-II antigen presentation in fibroblasts. Strongly CD-specific (delta_inflammation_CD=1.128), consistent with IFN-γ-dominant Th1 inflammation in Crohn's disease. Neighbor to M2 (Type I IFN) and M114 (MHC-I/immunoproteasome), forming a coherent interferon response neighborhood.
Genes
CALHM6, CD74, CXCL11, CXCL9, GBP4, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DRB5, IDO1
Most correlated modules
- NF-κB Inflammatory Activation · correlation 0.68
- FRC function · correlation 0.53
- Type I Interferon · correlation 0.43
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.