IDO1 — Indoleamine 2,3-dioxygenase 1
IDO1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IDO1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IFN-gamma Response Inflammation | APOL2, APOL6, BATF2, CARD16, CASP1, CD40, CXCL10, CXCL11 +18 more | View in SCUBA |
| Fibroblasts | IFN-γ MHC-II Response Inflammatory | CALHM6, CD74, CXCL11, CXCL9, GBP4, HLA-DPA1, HLA-DPB1, HLA-DQA1 +3 more | View in SCUBA |
| Glial cells | IFN-gamma Effector Program Inflammation | APOL1, APOL2, GBP1, IFI44L, IL18BP, IL32, LAP3, ODF3B +5 more | View in SCUBA |
| Macrophages | IFN-gamma Response Inflammatory | ANKRD22, APOL2, ATF5, ATP13A1, CD274, CD300LF, CD40, CD48 +21 more | View in SCUBA |
| Monocytes | Tolerogenic Monocyte Activation Inflammatory | CCR5, CD40, CD80, GGT5, IL4I1, MANF, PLA2G7, SLAMF7 +1 more | View in SCUBA |
About the gene
| Synonyms | IDO, INDO |
|---|---|
| Chromosome | 8: 39902275-39928790 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Dioxygenase, Oxidoreductase |
| Biological process | Immunity, Tryptophan catabolism |
Function
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.