CXCL11 — C-X-C motif chemokine ligand 11
CXCL11 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CXCL11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IFN-gamma Response Inflammation | APOL2, APOL6, BATF2, CARD16, CASP1, CD40, CXCL10, CXCL9 +18 more | View in SCUBA |
| Fibroblasts | IFN-γ MHC-II Response Inflammatory | CALHM6, CD74, CXCL9, GBP4, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DRA +3 more | View in SCUBA |
| Macrophages | IFN-gamma Response Inflammatory | ANKRD22, APOL2, ATF5, ATP13A1, CD274, CD300LF, CD40, CD48 +21 more | View in SCUBA |
| Monocytes | Monocyte Chemokine Secretion Inflammatory | ACOD1, ADAM19, CCL2, CCL7, CLEC5A, GBP3, IL27 | View in SCUBA |
About the gene
| Synonyms | b-R1, H174, I-TAC, IP-9, SCYB11, SCYB9B |
|---|---|
| Chromosome | 4: 76033682-76041415 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Human disease related genes, Predicted secreted proteins |
| Molecular function | Cytokine |
| Biological process | Chemotaxis, Inflammatory response |
Function
Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.