Autophagy Lysosomal
Gene co-expression module in Macrophages
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include TRAPPC5 (TRAPP complex, vesicle tethering/ER-to-Golgi trafficking), GABARAP (autophagy receptor/adaptor, ATG8 family), ATP6V0C (vacuolar H+-ATPase subunit c, lysosomal acidification), MAN2B1 (lysosomal alpha-mannosidase), EEF1G (translation elongation factor), RNASEK (RNase kappa, lysosomal), UBE2V1 (ubiquitin-conjugating enzyme), H1-4 and H1-2 (linker histones, enriched in prolif_mac suggesting cell cycle association), PSMB10 (immunoproteasome subunit). The module combines autophagy/lysosomal components (GABARAP, ATP6V0C, MAN2B1, RNASEK) with housekeeping translation and ubiquitin machinery. The histone genes (H1-4, H1-2) enriched in prolif_mac are likely peripheral members. The dominant program is autophagy/lysosomal trafficking. Small module (16 genes) with weak coherence.
Genes
APOC2, ATP6V0C, C18orf32, EEF1G, GABARAP, H1-2, H1-4, HES4, IFITM10, MAN2B1, NME2, PSMB10, RNASEK, SARNP, TRAPPC5, UBE2V1
Most correlated modules
- Integrated Stress Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.