PSMB10 — Proteasome 20S subunit beta 10
PSMB10 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PSMB10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Cytotoxic Effector Actin cytotoxicity | ARPC2, ARPC5, ATOX1, BRK1, CFL1, CLIC1, CORO1A, DBI +14 more | |
| Innate lymphoid cells | Septin Cytoskeleton Cytoskeleton & motility | ATP6V0C, C17orf49, CIAO2A, COX16, DARS1, DDOST, GET3, H2AC6 +18 more | View in SCUBA |
| Macrophages | Autophagy Lysosomal Lysosomal & pahgocytosis | APOC2, ATP6V0C, C18orf32, EEF1G, GABARAP, H1-2, H1-4, HES4 +7 more | View in SCUBA |
| Monocytes | Type I Interferon Response Antiviral | HEG1, IFITM1, IRF9, LY6E, MYOF, OAS1, PLAAT4, WARS1 | View in SCUBA |
| Mucosal-associated invariant T cell | Immunoproteasome Activity Inflammation | ABRACL, ARPC5, BANF1, CARD16, CISD3, CYBC1, GIMAP2, IMP3 +4 more | |
| Natural Killer cells | Histone Variant Remodeling DNA regulation & transcription | ARF5, C17orf49, DDOST, GNB2, H2AX, H2AZ1, H2AZ2, IFT25 +2 more | View in SCUBA |
About the gene
| Synonyms | beta2i, LMP10, MECL1, MGC1665 |
|---|---|
| Chromosome | 16: 67934506-67936864 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease, Threonine protease |
| Biological process | Host-virus interaction |
Function
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.