SARNP — SAP domain containing ribonucleoprotein
SARNP belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SARNP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Transcriptional Elongation Control DNA/chromatin regulation | ANP32B, AP2M1, ARF5, AURKAIP1, CCDC124, CUEDC2, CYC1, DCTN3 +19 more | |
| Macrophages | Autophagy Lysosomal Lysosomal & pahgocytosis | APOC2, ATP6V0C, C18orf32, EEF1G, GABARAP, H1-2, H1-4, HES4 +7 more | View in SCUBA |
About the gene
| Synonyms | CIP29, Hcc-1, THO1 |
|---|---|
| Chromosome | 12: 55752463-55817724 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding, RNA-binding |
| Biological process | mRNA transport, Transcription, Transcription regulation, Translation regulation, Transport |
Function
Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre- mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.