GABARAP — GABA type A receptor-associated protein
GABARAP belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GABARAP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | NKG2D Cytotoxic Activation cytotoxicity | CCND3, HCST, HDAC10, IER3IP1, IL2RG, KLRK1, KRTCAP2, LAMTOR4 +11 more | |
| Innate lymphoid cells | Mitochondrial Organization Mitochondrial & OxPhos | ARL5A, ATP5MJ, ATP5MK, BBLN, C18orf32, CIAO2B, CYRIB, EEF1G +21 more | View in SCUBA |
| Macrophages | Autophagy Lysosomal Lysosomal & pahgocytosis | APOC2, ATP6V0C, C18orf32, EEF1G, H1-2, H1-4, HES4, IFITM10 +7 more | View in SCUBA |
| Mucosal-associated invariant T cell | NADPH Oxidase & Innate Immune Inflammation | ATP5F1D, ATP5MC3, COX5A, CYBA, FXYD5, GNG5, HIGD2A, HINT1 +9 more | |
| Natural Killer cells | Mitochondrial Membrane Organization Mitochondrial & OxPhos | ATP5MJ, ATP5MK, BBLN, CIAO2B, H3-3A, MICOS10, PHB1, SEPTIN7 +1 more | View in SCUBA |
About the gene
| Synonyms | ATG8A, MM46 |
|---|---|
| Chromosome | 17: 7240008-7242449 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transporters |
| Biological process | Apoptosis, Autophagy, Protein transport, Transport |
Function
Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction. Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation. Involved in apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.