MAN2B1 — Mannosidase alpha class 2B member 1
MAN2B1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAN2B1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Immune Synapse Cytoskeleton Cytoskeletal | ARHGAP4, ARHGAP45, ATP2A3, CD48, DDOST, ICAM3, IL32, LAPTM5 +8 more | |
| Macrophages | Autophagy Lysosomal Lysosomal & pahgocytosis | APOC2, ATP6V0C, C18orf32, EEF1G, GABARAP, H1-2, H1-4, HES4 +7 more | View in SCUBA |
About the gene
| Synonyms | LAMAN, MANB |
|---|---|
| Chromosome | 19: 12646511-12666742 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Glycosidase, Hydrolase |
Function
Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.