SCUBA

HES4 — Hes family bHLH transcription factor 4

HES4 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

HES4's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsImmediate early response
BCR/AP1/NFKb pathway
CCNT1, CREM, JMY, JOSD1, KDM4B, NR4A3, PCNX4, PER1 +7 moreView in SCUBA
EndothelialNotch Arterial Identity
Endothelial cell development
ADAMTS1, ARID5A, BTG1, BTG2, CRIP1, DLL4, EFNA1, EFNB2 +14 moreView in SCUBA
FibroblastsCytokine Inflammatory Response
Inflammatory
CXCL2, DNAJB4, GFPT2, MAP3K8, MMP19, RASL11A, RGCC, RND3 +4 moreView in SCUBA
Gamma-delta T cellsAHR/NF-κB Survival
Immune regulation
ABCC1, AHR, ANKRD37, AREG, BAIAP2, BCL2L11, BEND4, BIRC3 +24 more
Glial cellsHyaluronan-CD44 Remodeling
ECM remodeling
C4orf48, CBX3, CD44, HAS2, MIA, PLEKHA4, WWTR1View in SCUBA
Goblet cellsNotch Secretory Specification
Epithelial development
EDN1, EREG, FKBP1A, GPRC5C, HES5, MYC, NOTCH2, PDGFA +4 moreView in SCUBA
Innate lymphoid cellsNF-κB Inflammatory Activation
Inflammation
AHI1, CD83, FAM107B, FKBP2, GADD45A, KDM6B, MRPS36, PRPF4B +7 moreView in SCUBA
MacrophagesAutophagy Lysosomal
Lysosomal & pahgocytosis
APOC2, ATP6V0C, C18orf32, EEF1G, GABARAP, H1-2, H1-4, IFITM10 +7 moreView in SCUBA
MonocytesMonocyte-Macrophage Differentiation
Developmental
ADGRE2, ADGRE3, BID, CYSLTR2, FAM110A, MARCKSL1, NRARP, PRELID1 +4 moreView in SCUBA
Mucosal-associated invariant T cellTissue Residency
Tissue residence
ACSL1, AMFR, CRACDL, DHX36, IRF8, ITGAE, LZTFL1, MACO1 +8 more
Smooth muscle cellsWnt-Notch Modulation
Development
CLMN, FRZB, LBH, MAP3K7CL, NET1, NRGN, NRIP2, PHLDA2 +1 moreView in SCUBA

About the gene

SynonymsbHLHb42
Chromosome1: 998962-1000172
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins, Transcription factors
Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Function

Transcriptional repressor. Binds DNA on N-box motifs: 5'- CACNAG-3' (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.