RNASEK — Ribonuclease K
RNASEK belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNASEK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | NKG2D Cytotoxic Activation cytotoxicity | CCND3, GABARAP, HCST, HDAC10, IER3IP1, IL2RG, KLRK1, KRTCAP2 +11 more | |
| Innate lymphoid cells | Mitochondrial Organization Mitochondrial & OxPhos | ARL5A, ATP5MJ, ATP5MK, BBLN, C18orf32, CIAO2B, CYRIB, EEF1G +21 more | View in SCUBA |
| Lymphatic endothelial | Mitochondrial Cristae Organization Mitochondrial & OxPhos | ATP5MJ, ATP6V0C, BEX4, EEF1G, EIF4A1, KRTCAP2, MICOS10, MICOS13 +6 more | View in SCUBA |
| Macrophages | Autophagy Lysosomal Lysosomal & pahgocytosis | APOC2, ATP6V0C, C18orf32, EEF1G, GABARAP, H1-2, H1-4, HES4 +7 more | View in SCUBA |
| Natural Killer cells | Interferon NK Activation Inflammation | CYRIB, IFITM1, KLRK1, NHERF1, PLAAT4, SEPTIN9, TLE5, UBE2V1 | View in SCUBA |
| Neutrophils | Heat Shock Response Stress | ATP6V0C, CYB5D1, DNAJA1, DUSP2, GNG10, HMOX1, HSP90AA1, HSP90AB1 +4 more |
About the gene
| Synonyms | MGC71993 |
|---|---|
| Chromosome | 17: 7012417-7014532 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Endonuclease, Hydrolase, Nuclease |
| Biological process | Endocytosis, Hydrogen ion transport, Ion transport, Transport |
Function
Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate. Regulates the activity of vacuolar (H+)-ATPase (V- ATPase) which is responsible for acidifying and maintaining the pH of intracellular compartments. Required at an early stage of receptor-mediated endocytosis. (Microbial infection) Required at an early stage of both clathrin-mediated and clathrin-independent endocytic uptake of a diverse set of viruses, including dengue, West Nile, Sindbis, Rift Valley Fever, influenza, and human rhinoviruses.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.