Cytoskeletal Migration
Gene co-expression module in Macrophages
| Category | Migration & adhesion |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
This small, weakly coherent module contains PAK1 (p21-activated kinase involved in cytoskeletal remodeling and cell migration), UNC5B (netrin receptor regulating axon guidance and vascular/cell migration), SIGLEC10 (inhibitory sialic acid-binding receptor), PALD1 (paladin, actin cytoskeleton regulator), EAF2 (transcription elongation factor), TBC1D4 (Rab GTPase activating protein), TPD52, and GLCCI1. PAK1, UNC5B, and PALD1 converge on cytoskeletal/migration regulation. The module is weakly defined but the cytoskeletal/migration theme is the most coherent signal.
Genes
EAF2, GLCCI1, PAK1, PALD1, SIGLEC10, TBC1D4, TPD52, UNC5B
Most correlated modules
- DNA Damage Repair · correlation 0.87
- Myeloid Signaling Regulation · correlation 0.84
- Macrophage Identity · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.