DNA Damage Repair
Gene co-expression module in Macrophages
| Category | Stress |
|---|---|
| Genes | 36 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 36 genes have a known function matching the annotation |
Why this annotation
ATM is the master kinase of the DNA double-strand break response. DCLRE1C (Artemis) is a nuclease essential for DNA end processing in non-homologous end joining. RNF169 is a ubiquitin E3 ligase recruited to DNA damage foci that regulates DSB repair pathway choice. These three genes form a coherent DNA damage response sub-theme. AKAP9 and AKNA are centrosome-associated scaffold proteins sometimes linked to DNA damage checkpoint signaling. The remaining genes (FGD2, ENTPD1, OSBPL1A, ATP10D, ABCC5) are functionally diverse, consistent with the weak coherence. The mild mono_mac enrichment of CREBRF is consistent with macrophage identity. The module is mixed but the DNA damage repair signature is the most identifiable coherent biological program.
Genes
ABCC5, ADAM28, AKAP9, AKNA, ATM, ATP10D, BAZ2A, CHD9, CREBRF, DCLRE1C, DDI2, DGLUCY, DHTKD1, DIP2A, EEA1, ENTPD1, EPHB2, FGD2, GAB3, KDM7A, MTR, OFD1, OSBPL1A, PGPEP1, PPARGC1B, RNF169, SCARB1, SPECC1, SRGAP3, SYMPK, TARBP1, TMEM144, TMEM268, TRPM2, YPEL2, ZDHHC21
Most correlated modules
- Myeloid Receptor Signaling · correlation 0.94
- Post-transcriptional Regulation · correlation 0.94
- Mixed Regulatory Signaling · correlation 0.92
- ER Stress Response · correlation 0.90
- Myeloid Signaling Regulation · correlation 0.90
- Cytoskeletal Migration · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.