SIGLEC10 — Sialic acid binding Ig like lectin 10
SIGLEC10 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SIGLEC10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR Signaling Regulation BCR/AP1/NFKb pathway | CBLB, CYTIP, FCRL2, FCRL3, G3BP2, HIVEP1, ITPR2, IVNS1ABP +5 more | View in SCUBA |
| Macrophages | Cytoskeletal Migration Migration & adhesion | EAF2, GLCCI1, PAK1, PALD1, TBC1D4, TPD52, UNC5B | View in SCUBA |
| Monocytes | Mitochondrial Immune Regulation Mitochondrial & OxPhos | CALHM2, CORO1B, DNASE2, DOK2, NDUFAF3, SLC39A1, UCP2 | View in SCUBA |
About the gene
| Synonyms | MGC126774, PRO940, SIGLEC-10, SLG2 |
|---|---|
| Chromosome | 19: 51410020-51417803 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Adaptive immunity, Cell adhesion, Immunity, Innate immunity |
Function
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells. Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8- alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.