TBC1D4 — TBC1 domain family member 4
TBC1D4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TBC1D4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA stability regulation Immune regulation | APLP2, ARID5B, CARHSP1, GK, GLCCI1, GRAMD4, HIVEP1, METTL8 +12 more | View in SCUBA |
| Endothelial | Venous EC Identity Endothelial cell development | ACTN1, AK4, CCL14, CTTNBP2, DAPK1, EPB41L3, FAM171A1, IL1R1 +18 more | View in SCUBA |
| Macrophages | Cytoskeletal Migration Migration & adhesion | EAF2, GLCCI1, PAK1, PALD1, SIGLEC10, TPD52, UNC5B | View in SCUBA |
About the gene
| Synonyms | AS160, DKFZp779C0666, KIAA0603 |
|---|---|
| Chromosome | 13: 75283503-75482169 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters |
| Molecular function | GTPase activation |
Function
May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.