UNC5B — Unc-5 netrin receptor B
UNC5B belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UNC5B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous Endothelial Identity Endothelial cell development | ACE, ADARB1, CDC42EP1, CLSTN1, EMCN, FLT1, GALNT18, GPRC5B +11 more | View in SCUBA |
| Fibroblasts | CYGB+ Quiescent Fibroblast Housekeeping | CCND1, CYGB, FARP1, FGFR4, FXYD5, NCAM1, NEGR1, NOVA1 +5 more | View in SCUBA |
| Macrophages | Cytoskeletal Migration Migration & adhesion | EAF2, GLCCI1, PAK1, PALD1, SIGLEC10, TBC1D4, TPD52 | View in SCUBA |
About the gene
| Synonyms | p53RDL1, UNC5H2 |
|---|---|
| Chromosome | 10: 71212570-71302864 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted membrane proteins |
| Molecular function | Developmental protein, Receptor |
| Biological process | Angiogenesis, Apoptosis |
Function
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as a netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.